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Continue to consider precautions related to pancreatic risk until more data are available

Full Answer: GLP-1 agonists like semaglutide and tirzepatide primarily reduce body weight by suppressing appetite and improving insulin signaling

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Peer review Peer review information Nature Metabolism thanks Xun Huang and the other, anonymous, reviewer for their contribution to the peer review of this work

That FDA-validated mechanism of action is exactly why we prescribe it: the evidence on visceral fat reduction is strong, and the compounded form makes it accessible to patients who simply want better body composition